|
Cytokines regulating eosinophilia |
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| Cytokine |
Family |
Effect on Eosinophils |
Other Relevant Functions |
|
|
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| TNF-α [59,60]
|
Monokine |
CAM expression, recruitment |
Vascular permeability increase, eosinophil degranulation |
| IL-1β [59,60]
|
Monokine |
CAM expression, eosinophil recruitment |
Eosinophil activation, eosinophil degranulation |
| IL-3 [59]
|
HP |
survival, differentiation |
Multipotential HP |
| IL-4 [59,60]
|
Th2 |
VCAM expression on EC |
IgE synthesis |
| IL-5 [59]
|
Th2 |
Hematopoiesis, activation, survival, mediator |
IgA synthesis |
| IL-13 [59,60]
|
Th2 |
VCAM expression on EC |
IgE synthesis, Mucus production |
| GM-CSF [59,60]
|
Th1/2 |
Activation |
MO activation, hematopoiesis |
| SCF [59]
|
HP |
Adhesion |
Mast cell growth |
| Eotaxins [59]
|
Chemokine |
Chemoattractant |
Multipotential HP |
| MCPs [59,60]
|
Chemokine |
Chemoattractant |
MO chemotaxis |
| RANTES [59,60]
|
Chemokine |
Chemoattractant |
Histamine release from basophils |
|
CAM, Cell Adhesion Molecule; EC, endothelial cells; CSF, Colony Stimulating Factor; Th2, type 2 T helper cell; HP, hematopoietin; APR, acute phase response, MO, Monocyte-macrophage lineage cells; VCAM-vascular cell adhesion molecule; MCP-monocyte chemoattractant protein-1 | |||
Copeland et al. Clinical and Molecular Allergy 2004 2:7 doi:10.1186/1476-7961-2-7 |
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