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Open Access Highly Accessed Case Report

Autoimmune progesterone dermatitis in a patient with endometriosis: case report and review of the literature

Alan P Baptist* and James L Baldwin

Author Affiliations

Division of Allergy/Immunology, Department of Internal Medicine, University of Michigan, 3918 Taubman Center, #0380, 1500 E Medical Center Drive, Ann Arbor, MI 48109-0380, USA

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Clinical and Molecular Allergy 2004, 2:10  doi:10.1186/1476-7961-2-10

Published: 2 August 2004

Abstract

Autoimmune progesterone dermatitis (APD) is a condition in which the menstrual cycle is associated with a number of skin findings such as urticaria, eczema, angioedema, and others. In affected women, it occurs 3–10 days prior to the onset of menstrual flow, and resolves 2 days into menses. Women with irregular menses may not have this clear correlation, and therefore may be missed. We present a case of APD in a woman with irregular menses and urticaria/angioedema for over 20 years, who had not been diagnosed or correctly treated due to the variable timing of skin manifestations and menses. In addition, we review the medical literature in regards to clinical features, pathogenesis, diagnosis, and treatment options.