Figure 2.

Areas in USA where IgE to alpha-gal is common and the associated tick. A: Map of United States of America with highlights on the south-eastern region in which reactions to cetuximab [51], as well as seropositivity to alpha-gal in delayed red meat allergy [48], are most prevalent. B: Lone star tick (Amblyomma americanum), most prevalent in southeast USA and linked to alpha-gal allergy [74-76]. Image used with permission from Iowa State University Entomology department; Credit to John VanDyk.