Table 4

Family-based Analysis of Association between IL12A and Asthma, Total IgE, and STR to Dust Mite among Children with Asthma in Costa Rica and CAMP
SNP (dbSNP
rs number)
 Chromosome
3 position
 Alleles
 Location
 Costa Ricans
 Whites




N*
 Model
 FBAT
p-value
 N*
 Model
 FBAT
p-value
Asthma








rs2243123
 161192344
 T>C
 Intron
 245
 a
 0.86
 301
 a
 0.58
rs2243151
 161198714
 A>T
 3'UTR
 277
 a
 0.46
 335
 a
 0.49
rs668998
 161198244
 A>G
 3'UTR
 282
 a
 0.96
 337
 a
 0.36
rs17826053
 161200322
 T>G
 3'UTR
 121
 a
 0.42
 203
 a
 0.14
Total IgE








rs2243123
 161192344
 T>C
 Intron
 245
 a
 0.30
 301
 a
 0.54
rs2243151
 161198714
 A>T
 3'UTR
 277
 a
 0.41
 335
 a
 0.60
rs668998
 161198244
 A>G
 3'UTR
 282
 a
 0.32
 337
 a
 0.47
rs17826053
 161200322
 T>G
 3'UTR
 121
 a
 0.61
 203
 a
 0.19
Positive IgE to D. pteronyssinus








rs2243123
 161192344
 T>C
 Intron
 245
 a
 0.30


rs2243151
 161198714
 A>T
 3'UTR
 277
 a
 0.43


rs668998
 161198244
 A>G
 3'UTR
 282
 a
 0.67


rs17826053
 161200322
 T>G
 3'UTR
 121
 a
 0.60


STR to D. pteronyssinus








rs2243123
 161192344
 T>C
 Intron
 244
 a
 0.95
 301
 a
 0.21
rs2243151
 161198714
 A>T
 3'UTR
 276
 a
 0.77
 335
 a
 0.18
rs668998
 161198244
 A>G
 3'UTR
 280
 a
 0.52
 337
 a
 0.10
rs17826053
 161200322
 T>G
 3'UTR
 120
 a
 0.43
 203
 a
 0.85

*Number of informative families

In Costa Rica, a positive IgE to D. pteronyssinus was defined as a value >= 0.35 IU/ml.

Allergen-specific IgE was not measured in CAMP.

Pistiner et al. Clinical and Molecular Allergy 2008 6:6   doi:10.1186/1476-7961-6-6