|
Family-based Analysis of Association between IL12A and Cockroach Sensitization among Children with Asthma in Costa Rica and White Children with Asthma in CAMP |
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| Costa Ricans |
CAMP |
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| SNP (dbSNP number) |
Chromosome 3 position |
Alleles |
Location |
N* |
Model |
FBAT P value |
N* |
Model |
FBAT P value |
|
|
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| Positive IgE to B. germanica |
|||||||||
| rs2243123 |
161192344 |
T>C |
Intron |
245 |
a |
+0.046 |
|||
| rs2243151 |
161198714 |
A>T |
3'UTR |
277 |
a |
0.05 |
|||
| 133 |
r |
+0.04 |
|||||||
| STR to P. Americana |
|||||||||
| rs2243123 |
161192344 |
T>C |
Intron |
244 |
a |
+0.03 |
301 |
a |
- |
| 84 |
r |
+0.002 |
94 |
r |
- |
||||
| rs2243151 |
161198714 |
A>T |
3'UTR |
276 |
a |
+0.03 |
335 |
a |
- |
| 133 |
r |
+0.01 |
169 |
r |
- |
||||
| rs17826053 |
161200322 |
T>G |
3'UTR |
120 |
a |
- |
203 |
a |
+0.02 |
| 119 |
r |
- |
198 |
r |
+0.01 |
||||
| STR to B. germanica |
|||||||||
| rs2243123 |
161192344 |
T>C |
Intron |
244 |
a |
- |
301 |
a |
- |
| 84 |
r |
+0.01 |
94 |
r |
0.09 |
||||
| rs2243151 |
161198714 |
A>T |
3'UTR |
276 |
a |
0.08 |
335 |
a |
0.09 |
| 133 |
r |
+0.0007 |
169 |
r |
-0.03 |
||||
| rs17826053 |
161200322 |
T>G |
3'UTR |
120 |
a |
- |
203 |
a |
+0.004 |
| 119 |
r |
- |
198 |
r |
+0.007 |
||||
|
*Number of informative families. STR = skin test reactivity. + and - signs preceding significant P values indicate the direction of the observed associations. In Costa Rica, a positive IgE to B. germanica was defined as a value >= 0.35 IU/ml. Allergen-specific IgE was not measured in CAMP. 3' UTR = 3' untranslated region. For ease of exposition, only p values < 0.1 are displayed. A dash "-" has been used to represent p values ≥ 0.1. | |||||||||
Pistiner et al. Clinical and Molecular Allergy 2008 6:6 doi:10.1186/1476-7961-6-6 |
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