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Fecal microbial diversity at ages 1 and 4 months, and eczema1 at age 6 months. |
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| Odds ratio2 (95% CI) |
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| Age |
Unadjusted |
Adjusted3 |
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| DGGE bands4 |
1 month |
0.61 (0.28–1.13) |
0.52 (0.19–1.08) |
| 4 months |
0.25 (0.04–0.87) |
0.19 (0.01–0.87) |
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| Shannon index5 |
1 month |
0.30 (0.08–0.80) |
0.23 (0.04–0.71) |
| 4 months |
0.15 (0.01–0.66) |
0.08 (0.01–0.58) |
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1Defined as maternal report of physician-diagnosed eczema at or before 6 months of age 2Odds ratio of having eczema if fecal microbial diversity (number of bands or Shannon index) increases from the mean value for cases to the mean value for controls (e.g. from 3.8 to 4.8 bands at 1 month, etc). 3Adjusted for mode of delivery and maternal history of atopy. Adjusted odds ratios were not significantly different than unadjusted ones. 4Number of denaturating gradient gel electrophoresis (DGGE) bands in each sample 5Shannon diversity index (H') calculated using the relative intensity of all bands within each sample | |||
Forno et al. Clinical and Molecular Allergy 2008 6:11 doi:10.1186/1476-7961-6-11 |
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