|
Characteristics of participating children |
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| Total n (%) |
Eczema1 n (%) |
Controls n (%) |
P-value2 |
|
|
|
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| Gender: |
||||
| -Male |
11 (52.4) |
4 (44.4) |
7 (58.3) |
0.67 |
| Mode of delivery: |
0.67 |
|||
| -Vaginal |
10 (47.6) |
5 (55.6) |
5 (41.7) |
|
| -Cesarean |
11 (52.4) |
4 (44.4) |
7 (58.3) |
|
| Maternal history of atopy |
12 (57.1) |
7 (77.8) |
5 (41.7) |
0.18 |
| Term delivery3 |
17 (81.0) |
7 (77.8) |
10 (83.3) |
1.00 |
| Birthweight (g), mean (SD) |
3319 (688) |
3192 (395) |
3415 (851) |
0.24 |
| 5-minute APGAR, median |
9 |
9 |
9 |
0.50 |
| Breastfed |
11 (52.4) |
6 (66.7) |
5 (41.7) |
0.39 |
| Daycare attendance |
5 (23.8) |
1 (11.1) |
4 (33.3) |
0.34 |
| Use of antibiotics4 |
3 (18.8) |
1 (16.7) |
2 (20.0) |
1.00 |
| Measures of bacterial diversity: |
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|
|
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| DGGE bands5, mean (95%CI): |
||||
| -1 month of age |
4.4 (3.6–5.1) |
3.8 (2.6–4.9) |
4.8 (3.8–5.9) |
0.10 |
| -4 months of age |
5.3 (3.8–6.7) |
3.9 (2.3–5.4) |
6.5 (4.2–8.8) |
0.06 |
| Shannon index6, mean (95%CI): |
||||
| -1 month of age |
0.66 (0.55–0.76) |
0.53 (0.38–0.67) |
0.75 (0.63–0.88) |
0.01 |
| -4 months of age |
0.77 (0.62–0.91) |
0.59 (0.38–0.81) |
0.92 (0.76–1.08) |
0.02 |
|
1 Defined as parental report of physician-diagnosed eczema at or before 6 months of age. 2Mann-Whitney P-values for the comparison between cases with eczema and controls. 3Birth between 37 and 41 weeks of gestation. 4Maternal report of antibiotic administration to the child 5Number of denaturating gradient gel electrophoresis (DGGE) bands in each sample 6Shannon H' index calculated using the relative intensity of all bands in each sample | ||||
Forno et al. Clinical and Molecular Allergy 2008 6:11 doi:10.1186/1476-7961-6-11 |
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