Systemic and local eosinophil inflammation during the birch pollen season in allergic patients with predominant rhinitis or asthma

Mary Kämpe¹^,2 , Gunnemar Stålenheim¹^,2 , Christer Janson¹^,2 , Ingrid Stolt²^,3 and Marie Carlson²^,3

¹Department of Medical Sciences, Respiratory Medicine and Allergology; University Hospital, Uppsala, Sweden

²Asthma Research Centre, University Hospital, Uppsala, Sweden

³Department of Medical Sciences, Gastroenterology Research Group, University Hospital, Uppsala, Sweden

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Clinical and Molecular Allergy 2007, 5:4doi:10.1186/1476-7961-5-4


Published:	29 October 2007

Abstract

Background

The aim of the study was to investigate inflammation during the birch pollen season in patients with rhinitis or asthma.

Methods

Subjects with birch pollen asthma (n = 7) or rhinitis (n = 9) and controls (n = 5) were studied before and during pollen seasons. Eosinophils (Eos), eosinophil cationic protein (ECP) and human neutrophil lipocalin were analysed.

Results

Allergic asthmatics had a larger decline in FEV1 after inhaling hypertonic saline than patients with rhinitis (median) (-7.0 vs.-0.4%, p = 0.02). The asthmatics had a lower sesonal PEFR than the rhinitis group. The seasonal increase in B-Eos was higher among patients with asthma (+0.17 × 109/L) and rhinitis (+0.27 × 109/L) than among controls (+0.01 × 109/L, p = 0.01). Allergic asthmatics and patients with rhinitis had a larger increase in sputum ECP (+2180 and +310 μg/L) than the controls (-146 μg/L, p = 0.02). No significant differences in inflammatory parameters were found between the two groups of allergic patients.

Conclusion

Patients with allergic asthma and rhinitis have the same degree of eosinophil inflammation. Despite this, only the asthmatic group experienced an impairment in lung function during the pollen season.