|
Correlation between Maternal Stool Bacteria and Cord Blood Cytokine Secretion by Mode of Delivery |
|||||
| Vaginal Delivery (n = 22) |
Cesarean Delivery (n = 15) |
||||
|
|
|
||||
| Maternal Stool Bacteria |
Stimulant |
Cytokines |
|||
|
|
|||||
| IL-13 |
|||||
|
|
|||||
| Gram-negative aerobes (Enterobacteriae) |
|||||
| rs* |
p-value |
rs* |
p-value |
||
|
|
|||||
| Media |
-0.38 |
0.08 |
0.52 |
0.06 |
|
| Fel d 1 |
-0.25 |
0.27 |
0.39 |
0.17 |
|
| Der f 1 |
-0.46 |
0.03 |
0.25 |
0.38 |
|
| PHA |
-0.28 |
0.21 |
-0.30 |
0.30 |
|
| LPS |
-0.35 |
0.11 |
0.14 |
0.62 |
|
|
|
|||||
| Gram-negative anaerobes (Bacteroides/Prevotella) |
|||||
| rs* |
p-value |
rs* |
p-value |
||
|
|
|||||
| Media |
-0.27 |
0.22 |
0.59 |
0.03 |
|
| Fel d 1 |
-0.22 |
0.34 |
0.70 |
0.006 |
|
| Der f 1 |
-0.40 |
0.07 |
0.49 |
0.07 |
|
| PHA |
-0.29 |
0.18 |
-0.36 |
0.21 |
|
| LPS |
-0.07 |
0.77 |
0.57 |
0.03 |
|
|
|
|||||
| IFN-γ |
|||||
|
|
|||||
| Gram-negative aerobes (Enterobacteriae) |
|||||
| rs* |
p-value |
rs* |
p-value |
||
|
|
|||||
| Media |
-0.52 |
0.01 |
-0.10 |
0.73 |
|
| Fel d 1 |
-0.53 |
0.01 |
0.04 |
0.90 |
|
| Der f 1 |
-0.47 |
0.03 |
0.04 |
0.90 |
|
| PHA |
-0.35 |
0.11 |
0.14 |
0.64 |
|
| LPS |
-0.50 |
0.02 |
0.22 |
0.44 |
|
|
|
|||||
| Gram-negative anaerobes (Bacteroides/Prevotella) |
|||||
| rs* |
p-value |
rs* |
p-value |
||
|
|
|||||
| Media |
-0.34 |
0.13 |
0.24 |
0.40 |
|
| Fel d 1 |
-0.30 |
0.17 |
0.36 |
0.21 |
|
| Der f 1 |
-0.41 |
0.06 |
0.45 |
0.11 |
|
| PHA |
-0.19 |
0.40 |
0.49 |
0.07 |
|
| LPS |
-0.15 |
0.50 |
0.58 |
0.03 |
|
|
|
|||||
| IL-10 |
|||||
|
|
|||||
| Gram-positive anaerobes (lactobacilli/bifidobacteria) |
|||||
| rs* |
p-value |
rs* |
p-value |
||
|
|
|||||
| Media |
0.35 |
0.11 |
± |
--- |
|
| Fel d 1 |
0.43 |
0.04 |
0.15 |
0.62 |
|
| Der f 1 |
0.45 |
0.03 |
0.30 |
0.30 |
|
| PHA |
-0.02 |
0.94 |
0.23 |
0.44 |
|
| LPS |
-0.03 |
0.89 |
0.23 |
0.42 |
|
|
|
|||||
| Total Anaerobes |
|||||
| rs* |
p-value |
rs* |
p-value |
||
|
|
|||||
| Media |
0.26 |
0.25 |
± |
---- |
|
| Fel d 1 |
0.48 |
0.03 |
0.12 |
0.69 |
|
| Der f 1 |
0.42 |
0.05 |
0.08 |
0.78 |
|
| PHA |
0.25 |
0.26 |
-0.22 |
0.44 |
|
| LPS |
0.26 |
0.25 |
-0.22 |
0.45 |
|
|
*Spearman's correlations. ± Correlation coefficients were not statistically obtainable due to undectectable IL-10 levels in the media samples (unstimulated CBMCs) among subjects in the cesarean section group. | |||||
Ly et al. Clinical and Molecular Allergy 2006 4:13 doi:10.1186/1476-7961-4-13 |
|||||