Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin

doi:10.1186/1476-7961-3-16

Clinical and Molecular Allergy

Volume 3

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Matheu V
Perez E
Hernández M
Díaz E
Darias R
González A
García JC
Sánchez I
Feliciano L
Caballero A
de la Torre F

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Matheu V
Perez E
Hernández M
Díaz E
Darias R
González A
García JC
Sánchez I
Feliciano L
Caballero A
de la Torre F
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Case Report

Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin

Victor Matheu¹ , Eva Perez² , Marta Hernández³ , Elisa Díaz² , Ricardo Darias⁴ , Abel González⁴ , Jose C García² , Inmaculada Sánchez² , Laura Feliciano⁵ , Agueda Caballero³ and Fernando de la Torre²

¹Medical Inflammation Research, Lund University, Sweden

²Allergy, Hospital Universitario NS Candelaria, Spain

³Endocrinology Service, Hospital Universitario de Canarias, Spain

⁴Endocrinology, Hospital Universitario NS Candelaria, Spain

⁵Dermatology Service, Hospital Universitario NS Candelaria, Spain

author email corresponding author email

Clinical and Molecular Allergy 2005, 3:16doi:10.1186/1476-7961-3-16


Published:	23 December 2005

Abstract

A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.