Case Report
Insulin allergy and resistance successfully treated by desensitisation with Aspart insulin
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* Corresponding author: Victor Matheu victor.matheu@med.lu.se
1 Medical Inflammation Research, Lund University, Sweden
2 Allergy, Hospital Universitario NS Candelaria, Spain
3 Endocrinology Service, Hospital Universitario de Canarias, Spain
4 Endocrinology, Hospital Universitario NS Candelaria, Spain
5 Dermatology Service, Hospital Universitario NS Candelaria, Spain
Clinical and Molecular Allergy 2005, 3:16 doi:10.1186/1476-7961-3-16
Published: 23 December 2005Abstract
A 25-year-old, with type I Diabetes Mellitus with a previous diagnosis of Protamine Allergy but not to human Insulin, started to notice anaphylactic reactions inmmediatly after bolus with Insulin. Skin prick and intradermal test were positive to all insulins. Skin tests to other potential allergens resulted negative. Examination after bolus of Human Insulin revealed urticaria. Daily insulin requirement were around 2-2,4 U/Kg/day. Slow desensitisation with Aspart insulin, the insulin with lowest size of skin test, was performed using subcutaneous insulin pump. Six months after the end of desensitisation his daily insulin requirement decreased to 0.8 U/Kg/day and oral corticosteroids are being reduced with no symptoms.